Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy
Forsthuber A*, Aschenbrenner B*, Korosec A*, Jacob T, Annusver K, Krajic N, Kholodniuk D, Frech S, Zhu S, Purkhauser K, Lipp K, Werner F, Nguyen V, Griss J, Bauer W, Soler Cardona A, Weber B, Weninger W, Gesslbauer B, Staud C, Nedomansky J, Radtke C, Wagner SN, Petzelbauer P, Kasper M#, Lichtenberger BM#.
Nature Communications. 2024 Nov 8;15(1):9678. doi: 10.1038/s41467-024-53908-9.
A prenatal skin atlas reveals immune regulation of human skin morphogenesis
Gopee NH, Winheim E, Olabi B, Admane C, Foster AR, Huang N, Botting RA, Torabi F, Sumanaweera D, Le AP, Kim J, Verger L, Stephenson E, Adão D, Ganier C, Gim KY, Serdy SA, Deakin C, Goh I, Steele L, Annusver K, Miah MU, Tun WM, Moghimi P, Kwakwa KA, Li T, Basurto Lozada D, Rumney B, Tudor CL, Roberts K, ... [28 authors]..., Rajan N, McGrath JA, O'Toole EA, Treutlein B, Bayraktar O, Kasper M, Progatzky F, Mazin P, Lee J, Gambardella L, Koehler KR, Teichmann SA, Haniffa M.
Nature. 2024 Nov;635(8039):679-689. doi: 10.1038/s41586-024-08002-x. Epub 2024 Oct 16.
Spatiotemporal Single-Cell Roadmap of Human Skin Wound Healing
Zhuang Liu, Dongqing Li, Xiaowei Bian, Lihua Luo, Åsa K. Björklund, Li Li, Letian Zhang, Yongjian Chen, Lei Guo, Juan Gao, Chunyan Cao, Jiating Wang, Wenjun He, Yunting Xiao, Liping Zhu, Karl Annusver, Huda Gopee, Clare L. Bennett, Maria Kasper, Muzlifah Haniffa, Pehr Sommar, Ning Xu Landén
bioRxiv 2024.08.30.609923; doi: https://doi.org/10.1101/2024.08.30.609923
Stimulation of skeletal stem cells in the growth plate promotes linear bone growth
Trompet D, Kurenkova AD, Zhou B, Li L, Dregval O, Usanova AP, Chu TL, Are A, Nedorubov AA, Kasper M, Chagin AS.
JCI Insight. 2024 Feb 13;9(6):e165226. doi: 10.1172/jci.insight.
Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.
Nguyen MB, Flora P, Branch MC, Weber M, Zheng XY, Sivan U, Joost S, Annusver K, Zheng D, Kasper M, Ezhkova E.
Sci Adv. 2024 Jan 19;10(3):eadi5791. doi: 10.1126/sciadv.adi5791. Epub 2024 Jan 19.
Plasticity of Epithelial Cells during Skin Wound Healing
Xiaoyan Sun#, Simon Joost, Maria Kasper#
Cold Spring Harb Perspect Biol. 2023;15(5):a041232.
ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
Mainwaring OJ, Weishaupt H, Zhao M, Rosén G, Borgenvik A, Breinschmid L, Verbaan AD, Richardson S, Thompson D, Clifford SC, Hill RM, Annusver K, Sundström A, Holmberg KO, Kasper M, Hutter S, Swartling FJ.
Nat Commun. 2023 Mar 3;14(1):1221.
Cell cycle controls long-range calcium signaling in the regenerating epidermis
Moore JL, Bhaskar D, Gao F, Matte-Martone C, Du S, Lathrop E, Ganesan S, Shao L, Norris R, Campamà Sanz N, Annusver K, Kasper M, Cox A, Hendry C, Rieck B, Krishnaswamy S, Greco V.
J Cell Biol. 2023 Jul 3;222(7):e202302095.
CAF variants control the tumor-immune microenvironment and predict skin cancer malignancy
Agnes Forsthuber, Ana Korosec, Tina Jacob, Bertram Aschenbrenner, Karl Annusver, Sophie Frech, Kim Purkhauser, Natalia Krajic, Katharina Lipp, Franziska Werner, Vy Nguyen, Johannes Griss, Wolfgang Bauer, Ana Soler Cardona, Benedikt Weber, Wolfgang Weninger, Bernhard Gesslbauer, Clement Staud, Jakob Nedomansky, Christine Radtke, Stephan N Wagner, Peter Petzelbauer, Maria Kasper#, Beate M Lichtenberger#
bioRxiv 2023.05.03.539213; doi: https://doi.org/10.1101/2023.05.03.539213
Injury prevents Ras mutant cell expansion in mosaic skin
Sara Gallini, Karl Annusver, Nur-Taz Rahman, David G. Gonzalez, Sangwon Yun, Catherine Matte-Martone, Tianchi Xin, Elizabeth Lathrop, Kathleen C. Suozzi, Maria Kasper# & Valentina Greco#.
Nature. 2023. https://doi.org/10.1038/s41586-023-06198-y
Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis
Matsuoka K, Bakiri L, Bilban M, Toegel S, Haschemi A, Yuan H, Kasper M, Windhager R, Wagner EF.
Ann Rheum Dis. 2023 Sep;82(9):1227-1239.
Skin mesenchymal niches maintain and protect AML-initiating stem cells
Sandhow L, Cai H, Leonard E, Xiao P, Tomaipitinca L, Månsson A, Kondo M, Sun X, Johansson AS, Tryggvason K, Kasper M, Järås M, Qian H.
J Exp Med. 2023 Oct 2;220(10):e20220953.
Molecular and spatial landmarks of early mouse skin development
Tina Jacob, Karl Annusver, Paulo Czarnewski, Tim Dalessandri, Christina Kalk, Chiara Levra Levron, Nil Campamà Sanz, Maria Eleni Kastriti, Marja L. Mikkola, Michael Rendl, Beate M. Lichtenberger, Giacomo Donati, Åsa K. Björklund, Maria Kasper.
Developmental Cell. 2023 Oct 23;58(20):2140-2162.e5.
Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation
Van Hove L, Toniolo A, Ghiasloo M, Lecomte K, Boone F, Ciers M, Raaijmakers K, Vandamme N, Roels J, Maschalidi S, Ravichandran KS, Kasper M, van Loo G, Hoste E.
Autophagy. 2023 Nov;19(11):2958-2971.
Injury suppresses Ras cell competitive advantage through enhanced wild-type cell proliferation
Sara Gallini, Nur-Taz Rahman*, Karl Annusver*, David G. Gonzalez, Sangwon Yun, Catherine Matte-Martone, Tianchi Xin, Elizabeth Lathrop, Kathleen C. Suozzi, Maria Kasper#, Valentina Greco#
bioRxiv 2022.01.05.475078; doi: https://doi.org/10.1101/2022.01.05.475078
A Mesenchymal Cell Niche in Skin for Acute Myeloid Leukemia
Lakshmi Sandhow, Huan Cai, Pingnan Xiao, Elory Leonard, Makoto Kondo, Xiaoyan Sun, Anne-Sofie Johansson, Karl Tryggvason, Maria Kasper, Marcus Järås, Hong Qian
bioRxiv 2022.05.20.491183; doi: https://doi.org/10.1101/2022.05.20.491183
Rare Gli1+ perivascular fibroblasts promote skin wound repair
Xiaoyan Sun#, Karl Annusver, Tim Dalessandri, Maria Kasper#.
bioRxiv 2022.05.16.491785; doi: https://doi.org/10.1101/2022.05.16.491785
Retrograde movements determine effective stem cell numbers in the intestine
Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J
Nature. 2022 Jul;607(7919):548-554.
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.
Cockburn K*, Annusver K*, Gonzalez DG, Ganesan S, May DP, Mesa KR, Kawaguchi K, Kasper M#, Greco V#.
Nat Cell Biol. 2022 Nov 10. doi: 10.1038/s41556-022-01021-8.
Molecular and spatial design of early skin development
Tina Jacob, Karl Annusver, Paulo Czarnewski, Tim Dalessandri, Maria Eleni Kastriti, Chiara Levra Levron, Marja L Mikkola, Michael Rendl, Beate M Lichtenberger, Giacomo Donati, Åsa Björklund, Maria Kasper
bioRxiv 2022.12.28.522081; doi: https://doi.org/10.1101/2022.12.28.522081
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
Larsson AJM, Ziegenhain C, Hagemann-Jensen M, Reinius B, Jacob T, Dalessandri T, Hendriks GJ, Kasper M, Sandberg R
PLoS Comput Biol. 2021 Mar 9;17(3):e1008772.
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer
Cockburn K*, Annusver K*, Ganesan S, Mesa KR, Kawaguchi K, Kasper M#, Greco V#
bioRxiv 2021.01.07.425777; doi: https://doi.org/10.1101/2021.01.07.425777
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
Hoste E, Lecomte K, Annusver K, Vandamme N, Roels J, Maschalidi S, Verboom L, Vikkula HK, Sze M, Van Hove L, Verstaen K, Martens A, Hochepied T, Saeys Y, Ravichandran K, Kasper M, van Loo G
Nature Communications. 2021 Oct 8;12(1):5913.
GLI1-induced mammary gland tumours are transplantable and maintain major molecular features.
Norum JH, Frings O, Kasper M, Bergholtz H, Zell Thime H, Bergström Å, Andersson A, Kuiper R, Fredlund E, Sørlie T, Toftgård R.
Int J Cancer. 2020 Feb 15;146(4): 1125-1138.
Cruciate ligament, patellar tendon and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds.
Zhang Y, Kameneva P, Annusver K, Kasper M, Chagin AS, Adameyko I, Xie M.
Dev Dyn. 2020 Feb 5. doi: 10.1002/dvdy.158.
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost S*, Annusver K*, Jacob T, Sun X, Dalessandri T, Sivan U, Sequeira I, Sandberg R, Kasper M
Cell Stem Cell. 2020 Mar 5;26(3):441-457.e7
Coordinated hedgehog signaling induces new hair follicles in adult skin
Sun X*, Are A*, Annusver K, Sivan U, Jacob T, Dalessandri T, Joost S, Füllgrabe A, Gerling M, Kasper M
eLife. 2020;9:e46756 (doi: 10.7554/eLife.46756)
Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis.
Zhang Y, Annusver K, Sunadome K, Kameneva P, Edwards S, Lei G, Kasper M, Chagin AS, Adameyko I, Xie M.
Front Cell Dev Biol. 2020 Mar 5;8:122. doi: 10.3389/fcell.2020.00122.
Cellular heterogeneity and microenvironmental control of skin cancer
Lichtenberger B, Kasper M
Journal of Internal Medicine. 2020 Sept 5. doi: 10.1111/joim.13177. REVIEW.
A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, Sovendahl L, Chagin AS.
Nature. 2019 Mar 567(7747):234-238.
Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent.
Mok KW, Saxena N, Heitman N, Grisanti L, Srivastava D, Muraro MJ, Jacob T, Sennett R, Wang Z, Su Y, Yang LM, Ma'ayan A, Ornitz DM, Kasper M, Rendl M.
Dev Cell. 2019 Jan 7.48(1):32-48.e5.
TREMendous Macrophages Inhibit Hair Growth.
Dalessandri T, Kasper M.
Cell Stem Cell. 2019 Apr 4;24(4):501-502.
Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.
Joost S, Jacob T, Sun X, Annusver K, La Manno G, Sur I, Kasper M.
Cell Rep. 2018 Oct 16.25(3):585-597.e7.
Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma.
Sternberg C, Gruber W, Eberl M, Tesanovic S, Stadler M, Elmer DP, Schlederer M, Grund S, Roos S, Wolff F, Kaur S, Mangelberger D, Lehrach H, Hache H, Wierling C, Laimer J, Lackner P, Wiederstein M, Kasper M, Risch A, Petzelbauer P, Moriggl R, Kenner L, Aberger F.
Int J Cancer. 2018 Dec1.143(11):2943-2954.
Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.
Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME, Xie M, Kicheva A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser M, Chagin AS, Fried K, Adameyko I.
Elife. 2018 Jun 13,7. pii: e34465.
Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population.
Acosta JR, Joost S, Karlsson K, Ehrlund A, Li X, Aouadi M, Kasper M, Arner P, Ryden M, Laurencikiene J.
Stem Cell Res Ther. 2017 Nov 7,8(1):250.
MicroRNA-132 with Therapeutic Potential in Chronic Wounds.
Li X, Li D, Wang A, Chu T, Lohcharoenkal W, Zheng X, Grunler J, Narayanan S, Eliasson S, Herter EK, Wang Y, Ma Y, Ehrstrom M, Eidsmo L, Kasper M, Pivarcsi A, Sonkoly E, Catrina SB, Stahle M, Xu Landen N.
J Invest Dermatol. 2017 Dec,137(12):2630-2638.
Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.
Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lonnerberg P, Linnarsson S#, Kasper M#.
Cell Systems 2016. 3. 1-17.
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.
Segerstolpe A*, Palasantza A*, Eliasson P, Andersson E-M, Andreasson A-C, Sun X, Picelli S, Sabirsh A, Clausen M, Bjursell MK, Smith DM, Kasper M, Anmala C and Sandberg R
Cell Metabolism. 2016. 24, 1-15.
Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing beta-Galactosidase.
Kasper M, Toftgard R. & Jaks V.
Methods Mol Biol. 2016,1453:123-36.
Dynamics of Lgr6+ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.
Fullgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgard R and Kasper M.
Stem Cell Reports. 2015. Nov 10,5(5):843-55.
Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo.
Hoelzl MA, Heby-Henricson K, Bilousova G, Rozell B, Kuiper RV, Kasper M, Toftgard R, Teglund S.
Stem Cells. Dev. 2015 Nov 1,24(21):2547-60
Quantitative single-cell RNA-seq with unique molecular identifiers.
Islam S, Zeisel A, Joost S, La Manno G, Zajac P, Kasper M, Lonnerberg P, Linnarsson S.
Nat Methods. 2014 Feb,11(2):163-6.
Smoothing out drug resistance.
Kasper M & Toftgard R.
Cancer Cell. 2013. Jan 14,23(1):3-5.
Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma.
Asklund T, Henriksson R, Axelsson J, Bergstrom A, Kasper M, Ogren M, Toftgard R, Alstrom Riklund K.
Acta Oncologica 2013. May,52(4):862-6.
Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus.
van Dop WA, Rosekrans SL, Uhmann A, Jaks V, Offerhaus GJ, van den Bergh Weerman MA, Kasper M, Heijmans J, Hardwick JC, Verspaget HW, Hommes DW, Toftgard R, Hahn H, van den Brink G.
Gut. 2013. Mar,62(3):348-57.
MicroRNA-203 Functions as a Tumor Suppressor in Basal Cell Carcinoma.
Sonkoly E, Loven J, Xu N, Meisgen F, Wei T, Brodin P, Jaks V, Kasper M, Shimokawa T, Harada M, Heilborn J, Hedblad MA, Hippe A, Grander D, Homey B, Zaphiropoulos P, Arsenian-Henriksson M, Stahle1 M, Pivarcsi A.
Oncogenesis. 2012. Mar 12,1:e3.
Basal Cell Carcinoma - molecular biology and potential new therapies.
Kasper M, Jaks V, Hohl D and Toftgard R.
J Clin Invest. 2012. Feb 1,122(2):455-63. REVIEW.
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.
Kasper M, Jaks V, Are A, Bergstrom A, Schwager A, Svard J, Teglund S, Barker N and Toftgard R.
Proc Natl Acad Sci USA. 2011. Mar 8,108(10):4099-104.
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H.
Science. 2010. Mar 12,327(5971):1385-9.
The Hair Follicle - a Stem Cell Zoo.
Jaks V*, Kasper M* and Toftgard R.
Exp Cell Res. 2010. May 1,316(8):1422-8. REVIEW.
Hedgehog signalling in breast cancer.
Kasper M, Jaks V, Fiaschi M, Toftgard R.
Carcinogenesis. 2009. Jun,30(6):903-11.
Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?
Gore SM, Kasper M, Williams T, Regl G, Aberger F, Cerio R, Neill GW, Philpott MP.
J Pathol. 2009. Sep,219(1):61-8.
Epidermal Growth Factor Receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation.
Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Sibilia M and Aberger F.
Cancer Res. 2009. Feb 15,69(4):1284-92.
LGR5 marks cycling, yet long-lived, hair follicle stem cells.
Jaks V*, Barker N*, Kasper M*, van Es JH, Snippert H, Clevers H and Toftgard R.
Nat Genet. 2008. Nov,40(11):1291-9.
Novel human GLI1 splice variants reveal distinct mechanisms in the terminal transduction of the Hedgehog signal.
Shimokawa T, Tostar U, Lauth M, Palaniswamy R, Kasper M, Toftgard R and Zaphiropoulos P.
J Biol Chem. 2008. May 23,283(21).
Very long-term self-renewal of small intestine, colon and hair follicles from cycling Lgr5+ve Stem Cells.
Barker N, van Es JH, Jaks V, Kasper M, Snippert H, Toftgard R and Clevers H.
Cold Spring Harb Symp Quant Biol. 2008. 73:351-6.
Efficient Manipulation of Hedgehog/GLI Signaling using Retroviral Expression Systems.
Kasper, M., Regl, G., Eichberger, T., Frischauf, A. M. and Aberger, F.
Methods Mol Biol. 2007. 397:67-78.
Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Kasper M, Schnidar H, Neill GW, Hanneder M, Klingler S, Blaas L, Schmid C, Hauser-Kronberger C, Regl G, Philpott MP, Aberger F.
Mol Cell Biol. 2006. Aug,26(16):6283-98.
GLI Transcription Factors: Mediators of Oncogenic Hedgehog Signalling.
Kasper M, Regl G, Frischauf AM, Aberger F.
Eur J Cancer. 2006. Mar,42(4):437-45. REVIEW.
RNA expression profiling at the single molecule level.
Hesse J, Jacak J, Kasper M, Regl G, Eichberger T, Winklmayr M, Aberger F, Sonnleitner M, Schlapak R, Howorka S, Muresan L, Frischauf AM, Schutz GJ.
Genome Res. 2006. Aug,16(8):1041-5.
Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes.
Eichberger T, Sander V, Schnidar H, Regl G, Kasper M, Schmid C, Plamberger S, Kaser A, Aberger F, Frischauf AM.
Genomics. 2006. May,87(5):616-32.
Ultra-sensitive DNA detection on microarrays.
Jacak J, Hesse J, Hesch C, Kasper M, Aberger F, Frischauf AM, Sonnleitner M, Freudenthaler G, Howorka S, and Schutz GJ.
SPIE. 2005. 5699, 442-9.
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.
Regl G*, Kasper M*, Schnidar H, Eichberger T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C, Frischauf AM, Aberger F.
Cancer Res. 2004. Nov 1,64(21):7724-31.
The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells.
Regl G, Kasper M, Schnidar H, Eichberger T, Neill GW, Ikram MS, Quinn AG, Philpott MP, Frischauf AM, Aberger F.
Oncogene. 2004. Feb 12,23(6):1263-74.
Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma.
Regl G, Neill GW, Eichberger T, Kasper M, Ikram MS, Koller J, Hintner H, Quinn AG, Frischauf AM, Aberger F.
Oncogene. 2002. Aug 15,21(36):5529-39.
© 2023 kasper lab