Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.
Nguyen MB, Flora P, Branch MC, Weber M, Zheng XY, Sivan U, Joost S, Annusver K, Zheng D, Kasper M, Ezhkova E.
Sci Adv. 2024 Jan 19;10(3):eadi5791. doi: 10.1126/sciadv.adi5791. Epub 2024 Jan 19.
Plasticity of Epithelial Cells during Skin Wound Healing
Xiaoyan Sun, Simon Joost, Maria Kasper
Cold Spring Harb Perspect Biol. 2023;15(5):a041232.
CAF variants control the tumor-immune microenvironment and predict skin cancer malignancy
Agnes Forsthuber, Ana Korosec, Tina Jacob, Bertram Aschenbrenner, Karl Annusver, Sophie Frech, Kim Purkhauser, Natalia Krajic, Katharina Lipp, Franziska Werner, Vy Nguyen, Johannes Griss, Wolfgang Bauer, Ana Soler Cardona, Benedikt Weber, Wolfgang Weninger, Bernhard Gesslbauer, Clement Staud, Jakob Nedomansky, Christine Radtke, Stephan N Wagner, Peter Petzelbauer, Maria Kasper, Beate M Lichtenberger
bioRxiv 2023.05.03.539213; doi: https://doi.org/10.1101/2023.05.03.539213
Injury prevents Ras mutant cell expansion in mosaic skin
Sara Gallini, Karl Annusver, Nur-Taz Rahman, David G. Gonzalez, Sangwon Yun, Catherine Matte-Martone, Tianchi Xin, Elizabeth Lathrop, Kathleen C. Suozzi, Maria Kasper & Valentina Greco
Nature. 2023. https://doi.org/10.1038/s41586-023-06198-y
Molecular and spatial landmarks of early mouse skin development
Tina Jacob, Karl Annusver, Paulo Czarnewski, Tim Dalessandri, Christina Kalk, Chiara Levra Levron, Nil Campamà Sanz, Maria Eleni Kastriti, Marja L. Mikkola, Michael Rendl, Beate M. Lichtenberger, Giacomo Donati, Åsa K. Björklund, Maria Kasper.
Developmental Cell. 2023 Oct 23;58(20):2140-2162.e5.
Rare Gli1+ perivascular fibroblasts promote skin wound repair
Xiaoyan Sun, Karl Annusver, Tim Dalessandri, Maria Kasper
bioRxiv 2022.05.16.491785; doi: https://doi.org/10.1101/2022.05.16.491785
Retrograde movements determine effective stem cell numbers in the intestine
Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J
Nature. 2022 Jul;607(7919):548-554.
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.
Cockburn K*, Annusver K*, Gonzalez DG, Ganesan S, May DP, Mesa KR, Kawaguchi K, Kasper M#, Greco V#.
Nat Cell Biol. 2022 Nov 10. doi: 10.1038/s41556-022-01021-8.
Molecular and spatial design of early skin development
Tina Jacob, Karl Annusver, Paulo Czarnewski, Tim Dalessandri, Maria Eleni Kastriti, Chiara Levra Levron, Marja L Mikkola, Michael Rendl, Beate M Lichtenberger, Giacomo Donati, Åsa Björklund, Maria Kasper
bioRxiv 2022.12.28.522081; doi: https://doi.org/10.1101/2022.12.28.522081
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer
Cockburn K*, Annusver K*, Ganesan S, Mesa KR, Kawaguchi K, Kasper M#, Greco V#
bioRxiv 2021.01.07.425777; doi: https://doi.org/10.1101/2021.01.07.425777
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, Sequeira I, Sandberg R, Kasper M
Cell Stem Cell. 2020 Mar 5;26(3):441-457.e7
Coordinated hedgehog signaling induces new hair follicles in adult skin
Sun X, Are A, Annusver K, Sivan U, Jacob T, Dalessandri T, Joost S, Füllgrabe A, Gerling M, Kasper M
eLife. 2020;9:e46756 (doi: 10.7554/eLife.46756)
Cellular heterogeneity and microenvironmental control of skin cancer
Lichtenberger B, Kasper M
Journal of Internal Medicine. 2020 Sept 5. doi: 10.1111/joim.13177. REVIEW.
A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, Sovendahl L, Chagin AS.
Nature. 2019 Mar 567(7747):234-238.
Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent.
Mok KW, Saxena N, Heitman N, Grisanti L, Srivastava D, Muraro MJ, Jacob T, Sennett R, Wang Z, Su Y, Yang LM, Ma'ayan A, Ornitz DM, Kasper M, Rendl M.
Dev Cell. 2019 Jan 7.48(1):32-48.e5.
Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.
Joost S, Jacob T, Sun X, Annusver K, La Manno G, Sur I, Kasper M.
Cell Rep. 2018 Oct 16.25(3):585-597.e7.
Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.
Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lonnerberg P, Linnarsson S, Kasper M.
Cell Systems 2016. 3. 1-17.
Dynamics of Lgr6+ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.
Fullgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgard R and Kasper M.
Stem Cell Reports. 2015. Nov 10,5(5):843-55.
Quantitative single-cell RNA-seq with unique molecular identifiers.
Islam S, Zeisel A, Joost S, La Manno G, Zajac P, Kasper M, Lonnerberg P, Linnarsson S.
Nat Methods. 2014 Feb,11(2):163-6.
Basal Cell Carcinoma - molecular biology and potential new therapies.
Kasper M, Jaks V, Hohl D and Toftgard R.
J Clin Invest. 2012. Feb 1,122(2):455-63. REVIEW.
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.
Kasper M, Jaks V, Are A, Bergstrom A, Schwager A, Svard J, Teglund S, Barker N and Toftgard R.
Proc Natl Acad Sci USA. 2011. Mar 8,108(10):4099-104.
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H.
Science. 2010. Mar 12,327(5971):1385-9.
The Hair Follicle - a Stem Cell Zoo.
Jaks V*, Kasper M* and Toftgard R.
Exp Cell Res. 2010. May 1,316(8):1422-8. REVIEW.
LGR5 marks cycling, yet long-lived, hair follicle stem cells.
Jaks V*, Barker N*, Kasper M*, van Es JH, Snippert H, Clevers H and Toftgard R.
Nat Genet. 2008. Nov,40(11):1291-9.
Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Kasper M, Schnidar H, Neill GW, Hanneder M, Klingler S, Blaas L, Schmid C, Hauser-Kronberger C, Regl G, Philpott MP, Aberger F.
Mol Cell Biol. 2006. Aug,26(16):6283-98.
GLI Transcription Factors: Mediators of Oncogenic Hedgehog Signalling.
Kasper M, Regl G, Frischauf AM, Aberger F.
Eur J Cancer. 2006. Mar,42(4):437-45. REVIEW.
RNA expression profiling at the single molecule level.
Hesse J, Jacak J, Kasper M, Regl G, Eichberger T, Winklmayr M, Aberger F, Sonnleitner M, Schlapak R, Howorka S, Muresan L, Frischauf AM, Schutz GJ.
Genome Res. 2006. Aug,16(8):1041-5.
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.
Regl G*, Kasper M*, Schnidar H, Eichberger T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C, Frischauf AM, Aberger F.
Cancer Res. 2004. Nov 1,64(21):7724-31.
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