Selected Publications

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2022

Injury suppresses Ras cell competitive advantage through enhanced wild-type cell proliferation
Sara Gallini, Nur-Taz Rahman*, Karl Annusver*, David G. Gonzalez, Sangwon Yun, Catherine Matte-Martone, Tianchi Xin, Elizabeth Lathrop, Kathleen C. Suozzi, Maria Kasper#, Valentina Greco#
bioRxiv 2022.01.05.475078; doi: https://doi.org/10.1101/2022.01.05.475078

Rare Gli1+ perivascular fibroblasts promote skin wound repair
Xiaoyan Sun, Karl Annusver, Tim Dalessandri, Maria Kasper
bioRxiv 2022.05.16.491785; doi: https://doi.org/10.1101/2022.05.16.491785

Retrograde movements determine effective stem cell numbers in the intestine
Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J
Nature. 2022 Jul;607(7919):548-554.

2021

Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer
Cockburn K*, Annusver K*, Ganesan S, Mesa KR, Kawaguchi K, Kasper M#, Greco V#
bioRxiv 2021.01.07.425777; doi: https://doi.org/10.1101/2021.01.07.425777

2020

The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, Sequeira I, Sandberg R, Kasper M
Cell Stem Cell. 2020 Mar 5;26(3):441-457.e7

Coordinated hedgehog signaling induces new hair follicles in adult skin
Sun X, Are A, Annusver K, Sivan U, Jacob T, Dalessandri T, Joost S, Füllgrabe A, Gerling M, Kasper M
eLife. 2020;9:e46756 (doi: 10.7554/eLife.46756)

Cellular heterogeneity and microenvironmental control of skin cancer
Lichtenberger B, Kasper M
Journal of Internal Medicine. 2020 Sept 5. doi: 10.1111/joim.13177. REVIEW.

2019

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, Sovendahl L, Chagin AS.
Nature. 2019 Mar 567(7747):234-238.

Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent.
Mok KW, Saxena N, Heitman N, Grisanti L, Srivastava D, Muraro MJ, Jacob T, Sennett R, Wang Z, Su Y, Yang LM, Ma'ayan A, Ornitz DM, Kasper M, Rendl M.
Dev Cell. 2019 Jan 7.48(1):32-48.e5.

2018

Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.
Joost S, Jacob T, Sun X, Annusver K, La Manno G, Sur I, Kasper M.
Cell Rep. 2018 Oct 16.25(3):585-597.e7.

2016

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.
Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lonnerberg P, Linnarsson S, Kasper M.
Cell Systems 2016. 3. 1-17.

2015

Dynamics of Lgr6+ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.
Fullgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgard R and Kasper M.
Stem Cell Reports. 2015. Nov 10,5(5):843-55.

2014

Quantitative single-cell RNA-seq with unique molecular identifiers.
Islam S, Zeisel A, Joost S, La Manno G, Zajac P, Kasper M, Lonnerberg P, Linnarsson S.
Nat Methods. 2014 Feb,11(2):163-6.

2012

Basal Cell Carcinoma - molecular biology and potential new therapies.
Kasper M, Jaks V, Hohl D and Toftgard R.
J Clin Invest. 2012. Feb 1,122(2):455-63. REVIEW.

2011

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.
Kasper M, Jaks V, Are A, Bergstrom A, Schwager A, Svard J, Teglund S, Barker N and Toftgard R.
Proc Natl Acad Sci USA. 2011. Mar 8,108(10):4099-104.

2010

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H.
Science. 2010. Mar 12,327(5971):1385-9.

The Hair Follicle - a Stem Cell Zoo.
Jaks V*, Kasper M* and Toftgard R.
Exp Cell Res. 2010. May 1,316(8):1422-8. REVIEW.

2008

LGR5 marks cycling, yet long-lived, hair follicle stem cells.
Jaks V*, Barker N*, Kasper M*, van Es JH, Snippert H, Clevers H and Toftgard R.
Nat Genet. 2008. Nov,40(11):1291-9.

2006

Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Kasper M, Schnidar H, Neill GW, Hanneder M, Klingler S, Blaas L, Schmid C, Hauser-Kronberger C, Regl G, Philpott MP, Aberger F.
Mol Cell Biol. 2006. Aug,26(16):6283-98.

GLI Transcription Factors: Mediators of Oncogenic Hedgehog Signalling.
Kasper M, Regl G, Frischauf AM, Aberger F.
Eur J Cancer. 2006. Mar,42(4):437-45. REVIEW.

RNA expression profiling at the single molecule level.
Hesse J, Jacak J, Kasper M, Regl G, Eichberger T, Winklmayr M, Aberger F, Sonnleitner M, Schlapak R, Howorka S, Muresan L, Frischauf AM, Schutz GJ.
Genome Res. 2006. Aug,16(8):1041-5.

2004

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.
Regl G*, Kasper M*, Schnidar H, Eichberger T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C, Frischauf AM, Aberger F.
Cancer Res. 2004. Nov 1,64(21):7724-31.


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