Cellular heterogeneity and microenvironmental control of skin cancer
Lichtenberger B, Kasper M
Journal of Internal Medicine. 2020 Sept 5. doi: 10.1111/joim.13177.

Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis.
Zhang Y, Annusver K, Sunadome K, Kameneva P, Edwards S, Lei G, Kasper M, Chagin AS, Adameyko I, Xie M.
Front Cell Dev Biol. 2020 Mar 5;8:122. doi: 10.3389/fcell.2020.00122.

Coordinated hedgehog signaling induces new hair follicles in adult skin
Sun X, Are A, Annusver K, Sivan U, Jacob T, Dalessandri T, Joost S, Füllgrabe A, Gerling M, Kasper M
eLife. 2020;9:e46756 (doi: 10.7554/eLife.46756)

The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
Joost S, Annusver K, Jacob T, Sun X, Dalessandri T, Sivan U, Sequeira I, Sandberg R and Kasper M
Cell Stem Cell. 2020 Mar 5;26(3):441-457.e7

Cruciate ligament, patellar tendon and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds.
Zhang Y, Kameneva P, Annusver K, Kasper M, Chagin AS, Adameyko I, Xie M.
Dev Dyn. 2020 Feb 5. doi: 10.1002/dvdy.158.

GLI1-induced mammary gland tumours are transplantable and maintain major molecular features.
Norum JH, Frings O, Kasper M, Bergholtz H, Zell Thime H, Bergström Å, Andersson A, Kuiper R, Fredlund E, Sørlie T, Toftgård R.
Int J Cancer. 2020 Feb 15;146(4): 1125-1138.


A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, Sun X, Sandhow L, Artemov AV, Ivashkin E, Suter S, Dyachuk V, El Shahawy M, Gritli-Linde A, Bouderlique T, Petersen J, Mollbrink A, Lundeberg J, Enikolopov G, Qian H, Fried K, Kasper M, Hedlund E, Adameyko I, Sovendahl L, Chagin AS.
Nature. 2019 Mar 567(7747):234-238.

Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent.
Mok KW, Saxena N, Heitman N, Grisanti L, Srivastava D, Muraro MJ, Jacob T, Sennett R, Wang Z, Su Y, Yang LM, Ma'ayan A, Ornitz DM, Kasper M, Rendl M.
Dev Cell. 2019 Jan 7.48(1):32-48.e5.

TREMendous Macrophages Inhibit Hair Growth.
Dalessandri T, Kasper M.
Cell Stem Cell. 2019 Apr 4;24(4):501-502.


Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.
Joost S, Jacob T, Sun X, Annusver K, La Manno G, Sur I, Kasper M.
Cell Rep. 2018 Oct 16.25(3):585-597.e7.

Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma.
Sternberg C, Gruber W, Eberl M, Tesanovic S, Stadler M, Elmer DP, Schlederer M, Grund S, Roos S, Wolff F, Kaur S, Mangelberger D, Lehrach H, Hache H, Wierling C, Laimer J, Lackner P, Wiederstein M, Kasper M, Risch A, Petzelbauer P, Moriggl R, Kenner L, Aberger F.
Int J Cancer. 2018 Dec1.143(11):2943-2954.

Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.
Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME, Xie M, Kicheva A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser M, Chagin AS, Fried K, Adameyko I.
Elife. 2018 Jun 13,7. pii: e34465.


Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population.
Acosta JR, Joost S, Karlsson K, Ehrlund A, Li X, Aouadi M, Kasper M, Arner P, Ryden M, Laurencikiene J.
Stem Cell Res Ther. 2017 Nov 7,8(1):250.

MicroRNA-132 with Therapeutic Potential in Chronic Wounds.
Li X, Li D, Wang A, Chu T, Lohcharoenkal W, Zheng X, Grunler J, Narayanan S, Eliasson S, Herter EK, Wang Y, Ma Y, Ehrstrom M, Eidsmo L, Kasper M, Pivarcsi A, Sonkoly E, Catrina SB, Stahle M, Xu Landen N.
J Invest Dermatol. 2017 Dec,137(12):2630-2638.


Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.
Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lonnerberg P, Linnarsson S, Kasper M.
Cell Systems 2016. 3. 1-17.

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.
Segerstolpe A*, Palasantza A*, Eliasson P, Andersson E-M, Andreasson A-C, Sun X, Picelli S, Sabirsh A, Clausen M, Bjursell MK, Smith DM, Kasper M, Anmala C and Sandberg R
Cell Metabolism. 2016. 24, 1-15.

Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing beta-Galactosidase.
Kasper M, Toftgard R. & Jaks V.
Methods Mol Biol. 2016,1453:123-36.


Dynamics of Lgr6+ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.
Fullgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgard R and Kasper M.
Stem Cell Reports. 2015. Nov 10,5(5):843-55.

Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo.
Hoelzl MA, Heby-Henricson K, Bilousova G, Rozell B, Kuiper RV, Kasper M, Toftgard R, Teglund S.
Stem Cells. Dev. 2015 Nov 1,24(21):2547-60


Quantitative single-cell RNA-seq with unique molecular identifiers.
Islam S, Zeisel A, Joost S, La Manno G, Zajac P, Kasper M, Lonnerberg P, Linnarsson S.
Nat Methods. 2014 Feb,11(2):163-6.


Smoothing out drug resistance.
Kasper M & Toftgard R.
Cancer Cell. 2013. Jan 14,23(1):3-5.

Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma.
Asklund T, Henriksson R, Axelsson J, Bergstrom A, Kasper M, Ogren M, Toftgard R, Alstrom Riklund K.
Acta Oncologica 2013. May,52(4):862-6.

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus.
van Dop WA, Rosekrans SL, Uhmann A, Jaks V, Offerhaus GJ, van den Bergh Weerman MA, Kasper M, Heijmans J, Hardwick JC, Verspaget HW, Hommes DW, Toftgard R, Hahn H, van den Brink G.
Gut. 2013. Mar,62(3):348-57.


MicroRNA-203 Functions as a Tumor Suppressor in Basal Cell Carcinoma.
Sonkoly E, Loven J, Xu N, Meisgen F, Wei T, Brodin P, Jaks V, Kasper M, Shimokawa T, Harada M, Heilborn J, Hedblad MA, Hippe A, Grander D, Homey B, Zaphiropoulos P, Arsenian-Henriksson M, Stahle1 M, Pivarcsi A.
Oncogenesis. 2012. Mar 12,1:e3.

Basal Cell Carcinoma - molecular biology and potential new therapies.
Kasper M, Jaks V, Hohl D and Toftgard R.
J Clin Invest. 2012. Feb 1,122(2):455-63.


Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.
Kasper M, Jaks V, Are A, Bergstrom A, Schwager A, Svard J, Teglund S, Barker N and Toftgard R.
Proc Natl Acad Sci USA. 2011. Mar 8,108(10):4099-104.


Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H.
Science. 2010. Mar 12,327(5971):1385-9.

The Hair Follicle - a Stem Cell Zoo.
Jaks V*, Kasper M* and Toftgard R.
Exp Cell Res. 2010. May 1,316(8):1422-8.


Hedgehog signalling in breast cancer.
Kasper M, Jaks V, Fiaschi M, Toftgard R.
Carcinogenesis. 2009. Jun,30(6):903-11.

Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?
Gore SM, Kasper M, Williams T, Regl G, Aberger F, Cerio R, Neill GW, Philpott MP.
J Pathol. 2009. Sep,219(1):61-8.

Epidermal Growth Factor Receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation.
Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Sibilia M and Aberger F.
Cancer Res. 2009. Feb 15,69(4):1284-92.


LGR5 marks cycling, yet long-lived, hair follicle stem cells.
Jaks V*, Barker N*, Kasper M*, van Es JH, Snippert H, Clevers H and Toftgard R.
Nat Genet. 2008. Nov,40(11):1291-9.

Novel human GLI1 splice variants reveal distinct mechanisms in the terminal transduction of the Hedgehog signal.
Shimokawa T, Tostar U, Lauth M, Palaniswamy R, Kasper M, Toftgard R and Zaphiropoulos P.
J Biol Chem. 2008. May 23,283(21).

Very long-term self-renewal of small intestine, colon and hair follicles from cycling Lgr5+ve Stem Cells.
Barker N, van Es JH, Jaks V, Kasper M, Snippert H, Toftgard R and Clevers H.
Cold Spring Harb Symp Quant Biol. 2008. 73:351-6.


Efficient Manipulation of Hedgehog/GLI Signaling using Retroviral Expression Systems.
Kasper, M., Regl, G., Eichberger, T., Frischauf, A. M. and Aberger, F.
Methods Mol Biol. 2007. 397:67-78.


Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Kasper M, Schnidar H, Neill GW, Hanneder M, Klingler S, Blaas L, Schmid C, Hauser-Kronberger C, Regl G, Philpott MP, Aberger F.
Mol Cell Biol. 2006. Aug,26(16):6283-98.

GLI Transcription Factors: Mediators of Oncogenic Hedgehog Signalling.
Kasper M, Regl G, Frischauf AM, Aberger F.
Eur J Cancer. 2006. Mar,42(4):437-45.

RNA expression profiling at the single molecule level.
Hesse J, Jacak J, Kasper M, Regl G, Eichberger T, Winklmayr M, Aberger F, Sonnleitner M, Schlapak R, Howorka S, Muresan L, Frischauf AM, Schutz GJ.
Genome Res. 2006. Aug,16(8):1041-5.

Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes.
Eichberger T, Sander V, Schnidar H, Regl G, Kasper M, Schmid C, Plamberger S, Kaser A, Aberger F, Frischauf AM.
Genomics. 2006. May,87(5):616-32.


Ultra-sensitive DNA detection on microarrays.
Jacak J, Hesse J, Hesch C, Kasper M, Aberger F, Frischauf AM, Sonnleitner M, Freudenthaler G, Howorka S, and Schutz GJ.
SPIE. 2005. 5699, 442-9.


Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.
Regl G*, Kasper M*, Schnidar H, Eichberger T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C, Frischauf AM, Aberger F.
Cancer Res. 2004. Nov 1,64(21):7724-31.

The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells.
Regl G, Kasper M, Schnidar H, Eichberger T, Neill GW, Ikram MS, Quinn AG, Philpott MP, Frischauf AM, Aberger F.
Oncogene. 2004. Feb 12,23(6):1263-74.


Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma.
Regl G, Neill GW, Eichberger T, Kasper M, Ikram MS, Koller J, Hintner H, Quinn AG, Frischauf AM, Aberger F.
Oncogene. 2002. Aug 15,21(36):5529-39.

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