Publications

2016

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity.
Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lonnerberg P, Linnarsson S, Kasper M.
Cell Systems 2016. 3. 1-17

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.
Segerstolpe A*, Palasantza A*, Eliasson P, Andersson E-M, Andreasson A-C, Sun X, Picelli S, Sabirsh A, Clausen M, Bjursell MK, Smith DM, Kasper M, Anmala C and Sandberg R
Cell Metabolism. 2016. 24, 1-15

Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing β-Galactosidase.
Kasper M, Toftgård R. & Jaks V.
Methods Mol Biol. 2016,1453:123-36.

2015

Dynamics of Lgr6+ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.
Füllgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgård R and Kasper M.
Stem Cell Reports. 2015. Nov 10,5(5):843-55.

Suppressor of Fused Plays an Important Role in Regulating. Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo.
Hoelzl MA, Heby-Henricson K, Bilousova G, Rozell B, Kuiper RV, Kasper M, Toftgård R, Teglund S.
Stem Cells. Dev. 2015 Nov 1,24(21):2547-60

2014

Quantitative single-cell RNA-seq with unique molecular identifiers.
Islam S, Zeisel A, Joost S, La Manno G, Zajac P, Kasper M, Lönnerberg P, Linnarsson S.
Nat Methods. 2014 Feb,11(2):163-6

2013

Smoothing out drug resistance.
Kasper M & Toftgård R.
Cancer Cell. 2013. Jan 14,23(1):3-5.

Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma.
Asklund T, Henriksson R, Axelsson J, Bergström Å, Kasper M, Ögren M, Toftgård R, Åhlström Riklund K.
Acta Oncologica 2013. May,52(4):862-6

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus.
van Dop WA, Rosekrans SL, Uhmann A, Jaks V, Offerhaus GJ, van den Bergh Weerman MA, Kasper M, Heijmans J, Hardwick JC, Verspaget HW, Hommes DW, Toftgård R, Hahn H, van den Brink G.
Gut. 2013. Mar,62(3):348-57

2012

MicroRNA-203 Functions as a Tumor Suppressor in Basal Cell Carcinoma.
Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, Jaks V, Kasper M, Shimokawa T, Harada M, Heilborn J, Hedblad MA, Hippe A, Grandér D, Homey B, Zaphiropoulos P, Arsenian-Henriksson M, Ståhle1 M, Pivarcsi A.
Oncogenesis. 2012. Mar 12,1:e3

Basal Cell Carcinoma – molecular biology and potential new therapies.
Kasper M, Jaks V, Hohl D and Toftgård R.
J Clin Invest. 2012. Feb 1,122(2):455-63

2011

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.
Kasper M, Jaks V, Are A, Bergström Å, Schwäger A, Svärd J, Teglund S, Barker N and Toftgård R.
Proc Natl Acad Sci USA. 2011. Mar 8,108(10):4099-104

2010

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H.
Science. 2010. Mar 12,327(5971):1385-9.

The Hair Follicle – a Stem Cell Zoo.
Jaks V*, Kasper M* and Toftgård R.
Exp Cell Res. 2010. May 1,316(8):1422-8

2009

Hedgehog signalling in breast cancer.
Kasper M, Jaks V, Fiaschi M, Toftgård R.
Carcinogenesis. 2009. Jun,30(6):903-11

Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?
Gore SM, Kasper M, Williams T, Regl G, Aberger F, Cerio R, Neill GW, Philpott MP.
J Pathol. 2009. Sep,219(1):61-8

Epidermal Growth Factor Receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation.
Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Sibilia M and Aberger F.
Cancer Res. 2009. Feb 15,69(4):1284-92.

2008

LGR5 marks cycling, yet long-lived, hair follicle stem cells.
Jaks V*, Barker N*, Kasper M*, van Es JH, Snippert H, Clevers H and Toftgård R.
Nat Genet. 2008. Nov,40(11):1291-9

Novel human GLI1 splice variants reveal distinct mechanisms in the terminal transduction of the Hedgehog signal.
Shimokawa T, Tostar U, Lauth M, Palaniswamy R, Kasper M, Toftgård R and Zaphiropoulos P.
J Biol Chem. 2008. May 23,283(21)

Very long-term self-renewal of small intestine, colon and hair follicles from cycling Lgr5+ve Stem Cells.
Barker N, van Es JH, Jaks V, Kasper M, Snippert H, Toftgård R and Clevers H.
Cold Spring Harb Symp Quant Biol. 2008. 73:351-6.

2007

Efficient Manipulation of Hedgehog/GLI Signaling using Retroviral Expression Systems.
Kasper, M., Regl, G., Eichberger, T., Frischauf, A. M. and Aberger, F.
Methods Mol Biol. 2007. 397:67-78.

2006

Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Kasper M, Schnidar H, Neill GW, Hanneder M, Klingler S, Blaas L, Schmid C, Hauser-Kronberger C, Regl G, Philpott MP, Aberger F.
Mol Cell Biol. 2006. Aug,26(16):6283-98

GLI Transcription Factors: Mediators of Oncogenic Hedgehog Signalling.
Kasper M, Regl G, Frischauf AM, Aberger F.
Eur J Cancer. 2006. Mar,42(4):437-45.

RNA expression profiling at the single molecule level.
Hesse J, Jacak J, Kasper M, Regl G, Eichberger T, Winklmayr M, Aberger F, Sonnleitner M, Schlapak R, Howorka S, Muresan L, Frischauf AM, Schutz GJ.
Genome Res. 2006. Aug,16(8):1041-5

Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes.
Eichberger T, Sander V, Schnidar H, Regl G, Kasper M, Schmid C, Plamberger S, Kaser A, Aberger F, Frischauf AM.
Genomics. 2006. May,87(5):616-32

2005

Ultra-sensitive DNA detection on microarrays.
Jacak J, Hesse J, Hesch C, Kasper M, Aberger F, Frischauf AM, Sonnleitner M, Freudenthaler G, Howorka S, and Schütz GJ.
SPIE. 2005. 5699, 442-9

2004

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.
Regl G*, Kasper M*, Schnidar H, Eichberger T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C, Frischauf AM, Aberger F.
Cancer Res. 2004. Nov 1,64(21):7724-31

The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells.
Regl G, Kasper M, Schnidar H, Eichberger T, Neill GW, Ikram MS, Quinn AG, Philpott MP, Frischauf AM, Aberger F.
Oncogene. 2004. Feb 12,23(6):1263-74.

2002

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma.
Regl G, Neill GW, Eichberger T, Kasper M, Ikram MS, Koller J, Hintner H, Quinn AG, Frischauf AM, Aberger F.
Oncogene. 2002. Aug 15,21(36):5529-39

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